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CD4 (T-helper) [WB]

GC Labs code	S528	Test Field	Hematology

GC Labs code

S528

Test Field

Hematology

Information

Test method	Flow cytometry
Specimen (mL)	EDTA WB 3.0
Specimen storage	Ambient
Specimen stability	Ambient (1 day)
Test schedule	Mon-Sat
Analytical time (day)	1

Test method

Flow cytometry

Specimen (mL)

EDTA WB 3.0

Specimen storage

Ambient

Specimen stability

Ambient (1 day)

Test schedule

Mon-Sat

Analytical time (day)

Reference range/Unit	[Whole Blood] 28.4 ~ 56.4 (%)
Clinical Significance	This is useful for serial monitoring of CD4 positive T cell count in patients who are HIV-positive and follow-up and diagnostic evaluation of primary immunodeficiencies, including severe combined immunodeficiency. Lymphocytes can be divided into three groups based on their biological functions and cell surface antigen characteristics. T lymphocytes, often referred to as T cells, play a role in antigen-specific cell-mediated immunity. They also regulate the synthesis and secretion of immunoglobulins in B lymphocytes. T cells can be further categorized into two functional subsets: helper/inducer T cells and suppressor/cytotoxic T cells, depending on their specific functions. Natural Killer (NK) cells are responsible for mediating cytotoxicity against cells infected with viruses or malignant tumors. They operate independently of the presence of major histocompatibility complexes in target tissues. A flow cytometric-based assay, using monoclonal antibodies specific to surface antigens, is used for differentiate lymphocytes to total T cells (CD3), suppressor T cells (CD8), helper T cells (CD4), B cells (CD19), and NK cells (CD16+CD56).
Compulsory forms
Remark	① Tests cannot be requested before Saturdays or public holidays ② Record the date of specimen collection

Reference range/Unit

 [Whole Blood]
28.4 ~ 56.4 (%)

Clinical Significance

This is useful for serial monitoring of CD4 positive T cell count in patients who are HIV-positive and follow-up and diagnostic evaluation of primary immunodeficiencies, including severe combined immunodeficiency.
Lymphocytes can be divided into three groups based on their biological functions and cell surface antigen characteristics.
T lymphocytes, often referred to as T cells, play a role in antigen-specific cell-mediated immunity. They also regulate the synthesis and secretion of immunoglobulins in B lymphocytes. T cells can be further categorized into two functional subsets: helper/inducer T cells and suppressor/cytotoxic T cells, depending on their specific functions.
Natural Killer (NK) cells are responsible for mediating cytotoxicity against cells infected with viruses or malignant tumors. They operate independently of the presence of major histocompatibility complexes in target tissues.
A flow cytometric-based assay, using monoclonal antibodies specific to surface antigens, is used for differentiate lymphocytes to total T cells (CD3), suppressor T cells (CD8), helper T cells (CD4), B cells (CD19), and NK cells (CD16+CD56).

Compulsory forms

Remark

① Tests cannot be requested before Saturdays or public holidays
② Record the date of specimen collection